Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA070937-02
Application #
2856419
Study Section
Radiation Study Section (RAD)
Program Officer
Mahoney, Francis J
Project Start
1998-01-01
Project End
2001-12-31
Budget Start
1998-07-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Cuneo, Kyle C; Geng, Ling; Fu, Allie et al. (2008) SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int J Radiat Oncol Biol Phys 71:873-9
Huamani, Jessica; Willey, Christopher; Thotala, Dinesh et al. (2008) Differential efficacy of combined therapy with radiation and AEE788 in high and low EGFR-expressing androgen-independent prostate tumor models. Int J Radiat Oncol Biol Phys 71:237-46
Geng, Ling; Cuneo, Kyle C; Cooper, Michael K et al. (2007) Hedgehog signaling in the murine melanoma microenvironment. Angiogenesis 10:259-67
Geng, Ling; Cuneo, Kyle C; Fu, Allie et al. (2006) Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res 66:11298-304
Cuneo, Kyle C; Geng, Ling; Tan, Jiahuai et al. (2006) SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. Int J Radiat Oncol Biol Phys 64:1197-203
Kuhn, Sam J; Hallahan, Dennis E; Giorgio, Todd D (2006) Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system. Ann Biomed Eng 34:51-8
Kim, Dong Wook Nathan; Huamani, Jessica; Niermann, Kenneth J et al. (2006) Noninvasive assessment of tumor vasculature response to radiation-mediated, vasculature-targeted therapy using quantified power Doppler sonography: implications for improvement of therapy schedules. J Ultrasound Med 25:1507-17
Tan, Jiahua; Geng, Ling; Yazlovitskaya, Eugenia M et al. (2006) Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium. Cancer Res 66:2320-7
Shinohara, Eric T; Geng, Ling; Tan, Jiahui et al. (2005) DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs. Cancer Res 65:4987-92
Geng, Ling; Osusky, Katherine; Konjeti, Sekhar et al. (2004) Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay. J Control Release 99:369-81

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