Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA071626-01
Application #
2115200
Study Section
Pathology B Study Section (PTHB)
Project Start
1996-08-20
Project End
2000-06-30
Budget Start
1996-08-20
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Abdel-Ghany, M; Cheng, H C; Elble, R C et al. (2001) The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis. J Biol Chem 276:25438-46
Fuller, C M; Ji, H L; Tousson, A et al. (2001) Ca(2+)-activated Cl(-) channels: a newly emerging anion transport family. Pflugers Arch 443 Suppl 1:S107-10
Pauli, B U; Abdel-Ghany, M; Cheng, H C et al. (2000) Molecular characteristics and functional diversity of CLCA family members. Clin Exp Pharmacol Physiol 27:901-5
Cheng, H C; Abdel-Ghany, M; Zhang, S et al. (1999) Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer? Clin Exp Metastasis 17:609-15
Gruber, A D; Pauli, B U (1999) Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31). Genome 42:1030-2
Gruber, A D; Pauli, B U (1999) Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2. Cancer Res 59:5488-91
Gruber, A D; Schreur, K D; Ji, H L et al. (1999) Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. Am J Physiol 276:C1261-70
Gruber, A D; Pauli, B U (1999) Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels. Biochim Biophys Acta 1444:418-23
Abdel-Ghany, M; Cheng, H; Levine, R A et al. (1998) Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells. Invasion Metastasis 18:35-43
Cheng, H C; Abdel-Ghany, M; Elble, R C et al. (1998) Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin. J Biol Chem 273:24207-15

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