Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA072039-01
Application #
2115515
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1996-09-01
Project End
2000-06-30
Budget Start
1996-09-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Yang, Jun; Singleton, David W; Shaughnessy, Elizabeth A et al. (2008) The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization. Mol Cell Endocrinol 295:94-100
Kojetin, Douglas J; Burris, Thomas P; Jensen, Elwood V et al. (2008) Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor. Endocr Relat Cancer 15:851-70
Feng, Yuxin; Manka, David; Wagner, Kay-Uwe et al. (2007) Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A 104:14718-23
Wang, Yong; Chirgadze, Nickolay Y; Briggs, Stephen L et al. (2006) A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta. Proc Natl Acad Sci U S A 103:9908-11
Singleton, David W; Feng, Yuxin; Yang, Jun et al. (2006) Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res 100:86-92
Singleton, David W; Feng, Yuxin; Chen, Yangde et al. (2004) Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol 221:47-55
Singleton, David W; Feng, Yuxin; Burd, Craig J et al. (2003) Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells. Endocrinology 144:121-8
Sheeler, Cameron Q; Singleton, David W; Khan, Sobhaib A (2003) Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocr Res 29:237-55
Puga, A; Barnes, S J; Chang, C et al. (2000) Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol 59:997-1005
Dudley, M W; Sheeler, C Q; Wang, H et al. (2000) Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action. Proc Natl Acad Sci U S A 97:3696-701

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