This research is in beginning stages. This year we designed and purchased equipment for behavioral testing,such as the Morris water maze,radial arm maze and fear conditioning. In addition, environmental enrichment cages and running wheel cages were designed and purchased. For the viral vector work we set up our tissue culture room and have begun preparing viral vectors. We have also injected vectors in to the dentate gyrus of the hippocampus of young adult C57Bl/6 mice. We are in the process of histological analysis of the data.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Institute on Aging
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Cooper, C'iana; Moon, Hyo Youl; van Praag, Henriette (2018) On the Run for Hippocampal Plasticity. Cold Spring Harb Perspect Med 8:
Mohammad, H; Marchisella, F; Ortega-Martinez, S et al. (2017) JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche. Mol Psychiatry :
Jongbloets, Bart C; Lemstra, Suzanne; Schellino, Roberta et al. (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666
Moon, Hyo Youl; Becke, Andreas; Berron, David et al. (2016) Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell Metab 24:332-40
Vivar, Carmen; Peterson, Benjamin D; van Praag, Henriette (2016) Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage 131:29-41
Duzel, Emrah; van Praag, Henriette; Sendtner, Michael (2016) Can physical exercise in old age improve memory and hippocampal function? Brain 139:662-73
Tweedie, David; Fukui, Koji; Li, Yazhou et al. (2016) Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms. PLoS One 11:e0156493
Guerrieri, Davide; van Praag, Henriette (2015) Exercise-mimetic AICAR transiently benefits brain function. Oncotarget 6:18293-313
Stringer, T P; Guerrieri, D; Vivar, C et al. (2015) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl Psychiatry 5:e493
Moon, Hyo Youl; van Praag, Henriette (2014) Muscle over mind. Cell Metab 20:560-2

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