This research is in progress. The hippocampus is crucial for memory formation. New neurons are added throughout life to the hippocampal dentate gyrus (DG), a brain area considered important for differential storage of similar experiences and contexts. To better understand the functional contribution of adult neurogenesis to pattern separation processes, we used a novel synapse specific trans-neuronal tracing approach to identify the (sub) cortical inputs to new dentate granule cells (GCs). It was observed that newly born neurons receive sequential innervation from structures important for memory function. Initially,septal-hippocampal cells provide input to new neurons, including transient innervation from mature GCs as well as direct feedback from area CA3 pyramidal neurons. After about 1 month perirhinal and lateral entorhinal cortex, brain areas deemed relevant to integration of novel sensory and environmental information, become substantial input to new GCs. The proposed functional relevance of new neurons, can now be examined within the context of their unique neural circuitry.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
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Cooper, C'iana; Moon, Hyo Youl; van Praag, Henriette (2018) On the Run for Hippocampal Plasticity. Cold Spring Harb Perspect Med 8:
Mohammad, H; Marchisella, F; Ortega-Martinez, S et al. (2017) JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche. Mol Psychiatry :
Jongbloets, Bart C; Lemstra, Suzanne; Schellino, Roberta et al. (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666
Moon, Hyo Youl; Becke, Andreas; Berron, David et al. (2016) Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell Metab 24:332-40
Vivar, Carmen; Peterson, Benjamin D; van Praag, Henriette (2016) Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage 131:29-41
Duzel, Emrah; van Praag, Henriette; Sendtner, Michael (2016) Can physical exercise in old age improve memory and hippocampal function? Brain 139:662-73
Tweedie, David; Fukui, Koji; Li, Yazhou et al. (2016) Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms. PLoS One 11:e0156493
Guerrieri, Davide; van Praag, Henriette (2015) Exercise-mimetic AICAR transiently benefits brain function. Oncotarget 6:18293-313
Stringer, T P; Guerrieri, D; Vivar, C et al. (2015) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl Psychiatry 5:e493
Moon, Hyo Youl; van Praag, Henriette (2014) Muscle over mind. Cell Metab 20:560-2

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