Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA078747-01A1
Application #
2901908
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Fu, Yali
Project Start
1999-09-01
Project End
2004-06-30
Budget Start
1999-09-01
Budget End
2000-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Chang, Chin-Yuan; Lohman, Jeremy R; Huang, Tingting et al. (2018) Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry 57:3278-3288
Chang, Chin-Yuan; Yan, Xiaohui; Crnovcic, Ivana et al. (2018) Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol 25:1075-1085.e4
Rudolf, Jeffrey D; Chang, Chin-Yuan; Ma, Ming et al. (2017) Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Nat Prod Rep 34:1141-1172
Annaval, Thibault; Rudolf, Jeffrey D; Chang, Chin-Yuan et al. (2017) Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. ACS Omega 2:5159-5169
Yan, Xiaohui; Ge, Huiming; Huang, Tingting et al. (2016) Strain Prioritization and Genome Mining for Enediyne Natural Products. MBio 7:
Huang, Tingting; Chang, Chin-Yuan; Lohman, Jeremy R et al. (2016) Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. J Antibiot (Tokyo) 69:731-740
Smanski, Michael J; Zhou, Hui; Claesen, Jan et al. (2016) Synthetic biology to access and expand nature's chemical diversity. Nat Rev Microbiol 14:135-49
Rudolf, Jeffrey D; Yan, Xiaohui; Shen, Ben (2016) Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. J Ind Microbiol Biotechnol 43:261-76
Li, Wenli; Li, Xiuling; Huang, Tingting et al. (2016) Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation. Bioorg Med Chem 24:3887-3892
Chang, Chin-Yuan; Lohman, Jeremy R; Cao, Hongnan et al. (2016) Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry 55:5142-54

Showing the most recent 10 out of 65 publications