Mevalonate Synthesis by Dietary Isoprenoids

Peffley, Dennis

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA081756-02
• Application #: 6150397
• Study Section: Nutrition Study Section (NTN)
• Program Officer: Clifford, Carolyn K
• Project Start: 1999-04-01
• Project End: 2000-07-01
• Budget Start: 2000-02-04
• Budget End: 2000-07-01
• Support Year: 2
• Fiscal Year: 2000
• Total Cost: $6,542

Institution

• Name: Rosalind Franklin University
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 069501252
• City: North Chicago
• State: IL
• Country: United States
• Zip Code: 60064

Publications

Peffley, Dennis M; Sharma, Catherine; Hentosh, Patricia et al. (2007) Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. Arch Biochem Biophys 465:266-73

Buechler, Robbie D; Peffley, Dennis M (2004) Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Mol Carcinog 41:39-53

Peffley, Dennis M; Gayen, Apurba K (2003) Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J Nutr 133:38-44

Hentosh, P; Yuh, S H; Elson, C E et al. (2001) Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells. Mol Carcinog 32:154-66