Mevalonate Synthesis by Dietary Isoprenoids

Peffley, Dennis

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA081756-05
• Application #: 6497561
• Study Section: Nutrition Study Section (NTN)
• Program Officer: Seifried, Harold E
• Project Start: 1999-04-01
• Project End: 2005-01-31
• Budget Start: 2002-02-01
• Budget End: 2005-01-31
• Support Year: 5
• Fiscal Year: 2002
• Total Cost: $203,076

Institution

• Name: Kansas City University of Medicine/Biosciences
• Department: Biochemistry
• Type: Schools of Osteopathy
• City: Kansas City
• State: MO
• Country: United States
• Zip Code: 64106

Publications

Peffley, Dennis M; Sharma, Catherine; Hentosh, Patricia et al. (2007) Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. Arch Biochem Biophys 465:266-73

Buechler, Robbie D; Peffley, Dennis M (2004) Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Mol Carcinog 41:39-53

Peffley, Dennis M; Gayen, Apurba K (2003) Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J Nutr 133:38-44

Hentosh, P; Yuh, S H; Elson, C E et al. (2001) Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells. Mol Carcinog 32:154-66