Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA082211-04
Application #
6513610
Study Section
Chemical Pathology Study Section (CPA)
Program Officer
Blair, Donald G
Project Start
1999-07-01
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2004-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$248,874
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Carrera, Samantha; de Verdier, Petra J; Khan, Zahid et al. (2010) Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis. J Biol Chem 285:13658-65
Macip, S; Kosoy, A; Lee, S W et al. (2006) Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint. Oncogene 25:6037-47
Ohtsuka, Takao; Ryu, Hoon; Minamishima, Yohji A et al. (2004) ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol 6:121-8
Kim, Kyung-Tae; Ongusaha, Pat P; Hong, Young-Kwon et al. (2004) Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem 279:38597-602
Macip, Salvador; Igarashi, Makoto; Berggren, Petra et al. (2003) Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 23:8576-85
Macip, Salvador; Igarashi, Makoto; Fang, Li et al. (2002) Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J 21:2180-8
Han, Jeong A; Kim, Jong-Il; Ongusaha, Pat P et al. (2002) P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J 21:5635-44
Fang, L; Li, G; Liu, G et al. (2001) p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J 20:1931-9
Fang, L; Lee, S W; Aaronson, S A (1999) Comparative analysis of p73 and p53 regulation and effector functions. J Cell Biol 147:823-30