Synthesis of CP-263,114 - New Ras Farnesylation Inhibitor

Davies, Huw M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA085641-03
• Application #: 6377796
• Study Section: Medicinal Chemistry Study Section (MCHA)
• Program Officer: Lees, Robert G
• Project Start: 1999-07-16
• Project End: 2003-06-30
• Budget Start: 2001-07-01
• Budget End: 2003-06-30
• Support Year: 3
• Fiscal Year: 2001
• Total Cost: $122,850

Institution

• Name: State University of New York at Buffalo
• Department: Chemistry
• Type: Schools of Arts and Sciences
• DUNS #: 038633251
• City: Buffalo
• State: NY
• Country: United States
• Zip Code: 14260

Publications

Nagashima, Tadamichi; Davies, Huw M L (2002) Catalytic asymmetric cyclopropanation using bridged dirhodium tetraprolinates on solid support. Org Lett 4:1989-92

Davies, H M; Townsend, R J (2001) Catalytic asymmetric cyclopropanation of heteroaryldiazoacetates. J Org Chem 66:6595-603

Davies, H M; Nagashima, T; Klino 3rd, J L (2000) Stereoselectivity of methyl aryldiazoacetate cyclopropanations of 1,1-diarylethylene. Asymmetric synthesis of a cyclopropyl analogue of tamoxifen. Org Lett 2:823-6