The goal of this research is to develop thermal therapy modeling techniques and prototype applicators that combine ultrasound (US) and radio-frequency (RF) electro-magnetic (EM) phased arrays which are designed for treating locally advanced cancer in the intact breast. The proposed hybrid RF/US applicators will combine regional RE heating with local US heating to improve the temperature distributions relative to those which are presently achievable in the clinic with adjuvant hyperthermia using RF or US applicators alone. These hybrid RE/US phased array devices will facilitate the clinical application of emerging cancer therapies, including the delivery and release of thermosensitive liposome-encapsulated drugs. The strategy for achieving this goal will: 1. evaluate parametric simulation models of the thermal distributions produced by hybrid RF/US applicators; 2. optimize beamforming approaches for the hybrid RF/US phased array system; and 3. design, develop, and test prototype hybrid RF/US thermal therapy systems for locally advanced breast cancer. The modeling approach will calculate RF field contributions and combine these results with simulations of US fields. The combined heating contributions produced by hybrid RE/US phased arrays will be optimized such that temperature distribution in the target volume is improved and problems with normal tissue heating are reduced or eliminated. The modeling and optimization results will also specify candidate geometries for RF/US phased array systems that target locally advanced cancer in the intact breast. Based on these modeling and optimization results, a prototype hybrid RF/US phased array system will be constructed. Anticipated success with the computer modeling, prototype construction, and preliminary device evaluation will ultimately translate into human clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA093669-03
Application #
6914910
Study Section
Radiation Study Section (RAD)
Program Officer
Deye, James
Project Start
2003-06-01
Project End
2007-05-31
Budget Start
2005-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2005
Total Cost
$232,085
Indirect Cost
Name
Michigan State University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
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Kelly, James F; McGough, Robert J (2008) Causal impulse response for circular sources in viscous media. J Acoust Soc Am 123:2107-16
Kelly, James F; McGough, Robert J (2007) An annular superposition integral for axisymmetric radiators. J Acoust Soc Am 121:759-65
Wu, Liyong; McGough, Robert J; Arabe, Omar Ali et al. (2006) An RF phased array applicator designed for hyperthermia breast cancer treatments. Phys Med Biol 51:1-20
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Chen, Duo; Kelly, James F; McGough, Robert J (2006) A fast near-field method for calculations of time-harmonic and transient pressures produced by triangular pistons. J Acoust Soc Am 120:2450-9
McGough, Robert J (2004) Rapid calculations of time-harmonic nearfield pressures produced by rectangular pistons. J Acoust Soc Am 115:1934-41
McGough, Robert J; Samulski, Thaddeus V; Kelly, James F (2004) An efficient grid sectoring method for calculations of the near-field pressure generated by a circular piston. J Acoust Soc Am 115:1942-54