Abstract

important and sometimes surprising insights into the complex regulation of p53. With these initial successes, I propose to continue to employ mouse genetics to investigate the roles of various phosphorylation and acetylation events in regulating p53 activity, and more importantly, in p53-dependent tumor suppression and aging in vivo. Project Description Page 6

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA094254-10
Application #
8204631
Study Section
Cancer Molecular Pathobiology Study Section (CAMP)
Program Officer
Johnson, Ronald L
Project Start
2001-07-01
Project End
2013-12-31
Budget Start
2012-01-01
Budget End
2013-12-31
Support Year
10
Fiscal Year
2012
Total Cost
$318,795
Indirect Cost
$112,455

  Institution

Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Lu, X; Mazur, S J; Lin, T et al. (2014) The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Oncogene 33:2655-64
Zhang, Zhen-Ning; Chung, Sun-Ku; Xu, Zheng et al. (2014) Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells 32:157-65
Kim, J; Nakasaki, M; Todorova, D et al. (2014) p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells. Cell Death Dis 5:e1141
Lu, X; Liu, D P; Xu, Y (2013) The gain of function of p53 cancer mutant in promoting mammary tumorigenesis. Oncogene 32:2900-6
Lake, Blue B; Fink, Jürgen; Klemetsaune, Liv et al. (2012) Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma. Stem Cells 30:888-97
Liu, Dongping; Xu, Yang (2011) p53, oxidative stress, and aging. Antioxid Redox Signal 15:1669-78
Liu, Dongping; Ou, Linda; Clemenson Jr, Gregory D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12:993-8
Liu, D P; Song, H; Xu, Y (2010) A common gain of function of p53 cancer mutants in inducing genetic instability. Oncogene 29:949-56
Gaidarenko, O; Xu, Y (2009) Transcription activity is required for p53-dependent tumor suppression. Oncogene 28:4397-401
Jenkins, Lisa M Miller; Mazur, Sharlyn J; Rossi, Matteo et al. (2008) Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Mol Cell Proteomics 7:716-27

Showing the most recent 10 out of 18 publications