Tobacco use is the major preventable cause of cancer and disease burden in the U.S. While effective treatments exist, innovative means of efficient delivery are needed to accelerate reduction in smoking prevalence. Telephone counseling and tailored self-change programs have an evidence-base of efficacy and the capability to make an impact on population prevalence. There is a growing movement to provide comprehensive tobacco control services, both through telephone quit lines and tailored self-change via the Internet. Scientists, policy makers and the public need to know if these programs work, for whom, by what mechanisms, and at what cost. There are no rigorous evaluations of the efficacy of Internet-driven cessation services or of combined telephone and Internet treatment At the same time, Internet-based programs are already available to the public and are being used at a very high volume without any evidence that they are effective. This study aims to extend existing theory and application by comparing the efficacy of a popular, full service, Internet intervention (Premium Internet) alone or in conjunction with proactive telephone counseling (Premium Internet plus Telephone) against a standard Internet control (Basic Interact). This study will recruit motivated smokers (N=2,055) who use an Internet search engine to find smoking cessation programs. A subset will be directed to a Web page that will describe the study and enrollment procedures. Using a 3-condition randomized design with repeated measures at baseline, 3, 6, 12, and 18-months post-randomization, consented smokers will be assigned to: 1) Basic Internet; 2) Premium Internet; and 3) Premium Internet plus Proactive Telephone Counseling. The hypotheses tested are that Premium Interact plus Telephone will outperform Premium Internet alone and both will outperform Basic Internet on 7-day point prevalence abstinence measured at 12 months post-randomization (6-months post treatment). Cost-effectiveness will also be examined along with exploratory analyses of theory-driven hypotheses about the mediators and moderators of outcome (e.g., gender, amount and frequency of service use, type of content used, and behavior change variables including self-efficacy, social support, and motivation). Market demand and State health departments are stimulating delivery of Interact and telephone cessation services. There is an urgent need for science to fill the gap and evaluate their efficacy. If effective, such treatments can be widely disseminated and can make a significant impact on population health.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA104836-03
Application #
7112950
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Parascandola, Mark
Project Start
2004-08-25
Project End
2006-09-30
Budget Start
2006-06-01
Budget End
2006-09-30
Support Year
3
Fiscal Year
2006
Total Cost
$30,255
Indirect Cost
Name
Brown University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Graham, Amanda L; Papandonatos, George D; Cha, Sarah et al. (2018) Improving Adherence to Smoking Cessation Treatment: Smoking Outcomes in a Web-based Randomized Trial. Ann Behav Med 52:331-341
Papandonatos, George D; Erar, Bahar; Stanton, Cassandra A et al. (2016) Online community use predicts abstinence in combined Internet/phone intervention for smoking cessation. J Consult Clin Psychol 84:633-44
Graham, Amanda L; Papandonatos, George D; Erar, Bahar et al. (2015) Use of an online smoking cessation community promotes abstinence: Results of propensity score weighting. Health Psychol 34S:1286-95
Graham, Amanda L; Papandonatos, George D; Cobb, Caroline O et al. (2015) Internet and Telephone Treatment for smoking cessation: mediators and moderators of short-term abstinence. Nicotine Tob Res 17:299-308
Cobb, Caroline O; Niaura, Raymond S; Donaldson, Elisabeth A et al. (2014) Quit now? Quit soon? Quit when you're ready? Insights about target quit dates for smoking cessation from an online quit date tool. J Med Internet Res 16:e55
Cobb, Caroline O; Graham, Amanda L (2014) Use of non-assigned interventions in a randomized trial of internet and telephone treatment for smoking cessation. Nicotine Tob Res 16:1289-97
Graham, Amanda L; Chang, Yaojen; Fang, Ye et al. (2013) Cost-effectiveness of internet and telephone treatment for smoking cessation: an economic evaluation of The iQUITT Study. Tob Control 22:e11
Graham, Amanda L; Papandonatos, George D; Kang, Hakmook et al. (2011) Development and validation of the online social support for smokers scale. J Med Internet Res 13:e69
Graham, Amanda L; Cobb, Nathan K; Papandonatos, George D et al. (2011) A randomized trial of Internet and telephone treatment for smoking cessation. Arch Intern Med 171:46-53
Cobb, Nathan K; Graham, Amanda L; Abrams, David B (2010) Social network structure of a large online community for smoking cessation. Am J Public Health 100:1282-9

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