Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA157268-05S1
Application #
9079771
Study Section
Special Emphasis Panel (ZRG1-OBT-Z (02))
Program Officer
Lin, Alison J
Project Start
2011-09-01
Project End
2016-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
5
Fiscal Year
2015
Total Cost
$67,263
Indirect Cost
$21,297
Name
Duke University
Department
Genetics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Bisogno, Laura S; Friedersdorf, Matthew B; Keene, Jack D (2018) Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion. iScience 4:97-108
Bisogno, Laura Simone; Keene, Jack Donald (2018) RNA regulons in cancer and inflammation. Curr Opin Genet Dev 48:97-103
Fry, Nate J; Law, Brittany A; Ilkayeva, Olga R et al. (2018) N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. Oncotarget 9:31231-31243
Nicholson, Cindo O; Friedersdorf, Matthew B; Bisogno, Laura S et al. (2017) DO-RIP-seq to quantify RNA binding sites transcriptome-wide. Methods 118-119:16-23
Nicholson, Cindo O; Friedersdorf, Matthew; Keene, Jack D (2017) Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq. RNA 23:32-46
Bisogno, Laura S; Keene, Jack D (2017) Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis. Methods 126:193-200
Smola, Matthew J; Christy, Thomas W; Inoue, Kaoru et al. (2016) SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells. Proc Natl Acad Sci U S A 113:10322-7
Blackinton, Jeff G; Keene, Jack D (2016) Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation. Nucleic Acids Res 44:426-36
Moon, Stephanie L; Blackinton, Jeffrey G; Anderson, John R et al. (2015) XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability. PLoS Pathog 11:e1004708
Friedersdorf, Matthew B; Keene, Jack D (2014) Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs. Genome Biol 15:R2

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