The overall objective is to characterize the effects of PCP, in comparison to other abused drugs, on complex operant behavior in monkeys and pigeons. The first series of experiments will compare PCP with a variety of other drugs reported to have hallucinogenic effects, namely, MDMA, LSD, DMT, psilocybin, mescaline, DOM, ketamine, d-SKF 10047, dexoxadrol, etoxadrol, and scopolamine. The behavioral baseline will be a multiple schedule of repeated acquisition (""""""""learning"""""""") and performance of four-response chains in patas monkeys, and dose-effect data will be obtained for each drug. The second series of experiments will use a similar baseline to compare the same drugs in pigeons. In the third and fourth series of experiments, PCP will be compared with four prototype drugs (d-amphetamine, pentobarbital, LSC, and scopolamine) in patas monkeys and pigeons responding in a """"""""memory"""""""" task involving repeated acquisition and delayed performance. With this baseline, one can determine the extent to which the subjects can """"""""remember"""""""", after varying delays, the particular four-response chain they acquired during a given session. These experiments will also determine whether """"""""overlearning"""""""" attenuates the effects of the drugs on retention. The methodology in the proposed research is important because it provides the means for studying drug effects on learning and memory in individual subjects. This point is especially relevant to studying PCP's effects since there are often marked individual differences in the response to PCP in both animals and humans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001528-12
Application #
3206931
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1976-06-29
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1990-06-30
Support Year
12
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Georgetown University
Department
Type
School of Medicine & Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Winsauer, P J; Thompson, D M (1992) Differential interaction of cholecystokinin with morphine and phencyclidine: effects on operant behavior in pigeons. Pharmacol Biochem Behav 41:83-90
Winsauer, P J; Thompson, D M (1991) Cocaine self-administration in pigeons. Pharmacol Biochem Behav 40:41-52
Thompson, D M; Winsauer, P J; Mastropaolo, J (1987) Effects of phencyclidine, ketamine and MDMA on complex operant behavior in monkeys. Pharmacol Biochem Behav 26:401-5
Thompson, D M; Mastropaolo, J; Winsauer, P J et al. (1986) Repeated acquisition and delayed performance as a baseline to assess drug effects on retention in monkeys. Pharmacol Biochem Behav 25:201-7
Thompson, D M; Winsauer, P J (1986) Nicotine can attenuate the disruptive effects of phencyclidine on repeated acquisition in monkeys. Pharmacol Biochem Behav 25:185-90
Thompson, D M; Winsauer, P J (1985) Delta-9-tetrahydrocannabinol potentiates the disruptive effects of phencyclidine on repeated acquisition in monkeys. Pharmacol Biochem Behav 23:1051-7
Moerschbaecher, J M; Thompson, D M; Winsauer, P J (1985) Effects of opioids and phencyclidine in combination with naltrexone on the acquisition and performance of response sequences in monkeys. Pharmacol Biochem Behav 22:1061-9
Thompson, D M; Winsauer, P J (1985) Cocaine potentiates the disruptive effects of phencyclidine on repeated acquisition in monkeys. Pharmacol Biochem Behav 23:823-9
Winsauer, P J; Thompson, D M; Moerschbaecher, J M (1985) Comparison of drug effects on fixed-ratio performance and chain performance maintained under a second-order fixed-ratio schedule. J Exp Anal Behav 44:367-76