Abstract

This project proposes to use electrophysiological and behavioral techniques such as brain wave measurements, single nerve cell recordings and stimulus discrimination behavior to better define the sites and mechanisms of action of phencyclidine and derivatives. A systematic evaluation of the role of behavioral and pharmacological factors in tolerance, physical dependence and withdrawal reaction to phencyclidine and possible methods of treatment will then be undertaken. The subjects of this research will be albino rats and Macaca mulatta monkeys.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001531-05
Application #
3206941
Study Section
(DABA)
Project Start
1985-09-30
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Xu, X; Domino, E F (1994) Phencyclidine-induced behavioral sensitization. Pharmacol Biochem Behav 47:603-8
Xu, X; Domino, E F (1994) Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801. Neurochem Int 25:155-9
Holsztynska, E J; Weber, W W; Domino, E F (1991) Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans. Drug Metab Dispos 19:48-53
Pohorecki, R; Rayburn, W; Coon, W W et al. (1989) Some factors affecting phencyclidine biotransformation by human liver and placenta. Drug Metab Dispos 17:271-4
Gole, D J; Pirat, J L; Kamenka, J M et al. (1988) Hydroxy metabolites of phencyclidine. Identification and quantitation of two novel metabolites. Drug Metab Dispos 16:386-91
Domino, E F; Gole, D; Koek, W (1987) Metaphit, a proposed phencyclidine receptor acylator: disruption of mouse motor behavior and absence of PCP antagonist activity. J Pharmacol Exp Ther 243:95-100
Holsztynska, E J; Domino, E F (1986) Quantitation of phencyclidine, its metabolites, and derivatives by gas chromatography with nitrogen-phosphorus detection: application for in vivo and in vitro biotransformation studies. J Anal Toxicol 10:107-15
Lal, J; Krutak-Krol, H; Domino, E F (1986) Comparative antitussive effects of dextrorphan, dextromethorphan and phencyclidine. Arzneimittelforschung 36:1075-8
Domino, E F (1986) Comparison of phencyclidine and related substances with various indole, phenethylamine, and other psychotomimetics. Psychopharmacol Bull 22:973-6
Holsztynska, E J; Domino, E F (1985) Biotransformation of phencyclidine. Drug Metab Rev 16:285-320