The UCLA Drug Abuse Research Center, in collaboration with the Matrix Institute on Addictions, is resubmitting a proposal for a 42-month project to examine the effectiveness of levo-alpha-aceyl methadol (LAAM) as a treatment intervention for high-risk heroin addicts with AIDS prevention aspects equal or superior to methadone maintenance (MM). The proposed study uses a repeated measures design which involves randomly assigning 300 addicts (initially selected subjects and subjects to replace attrition) to two groups, MM or LAAM maintenance, for a period of twelve months of subsidized treatment. All subjects will be assessed at the beginning of treatment, at six months, twelve months, and eighteen months after treatment entry.
The specific aims of the study are: (1) to test the overall effectiveness of LAAM in reducing high-risk behaviors associated with HIV infection; (2) to determine which medication and patient characteristics contribute to improved long-term retention and clinic attendance in LAAM treatment compared with MM treatment; and (3) to compare the effectiveness of LAAM and MM in reducing HIV risk behaviors associated with heroin addiction, particularly as related to subject demographic and psychosocial characteristics. The proposed project will use repeated measures ANOVA, survival analyses, and multiple or logistic regression analyses to assess these aims.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA010422-02
Application #
2517994
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1996-09-30
Project End
2000-07-31
Budget Start
1997-09-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Hellemann, Gerhard; Conner, Bradley T; Anglin, M Douglas et al. (2009) Seeing the trees despite the forest: applying recursive partitioning to the evaluation of drug treatment retention. J Subst Abuse Treat 36:59-64
Longshore, Douglas; Anglin, M Douglas; Conner, Bradley T (2009) Are religiosity and spirituality useful constructs in drug treatment research? J Behav Health Serv Res 36:177-88
Conner, Bradley T; Anglin, M Douglas; Annon, Jeffery et al. (2009) Effect of religiosity and spirituality on drug treatment outcomes. J Behav Health Serv Res 36:189-98
Anglin, M Douglas; Conner, Bradley T; Annon, Jeffrey J et al. (2009) Longitudinal effects of LAAM and methadone maintenance on heroin addict behavior. J Behav Health Serv Res 36:267-82
Anglin, M Douglas; Conner, Bradley T; Annon, Jeffery et al. (2007) Levo-alpha-acetylmethadol (LAAM) versus methadone maintenance: 1-year treatment retention, outcomes and status. Addiction 102:1432-42
Longshore, Douglas; Annon, Jeffrey; Anglin, M Douglas et al. (2005) Levo-alpha-acetylmethadol (LAAM) versus methadone: treatment retention and opiate use. Addiction 100:1131-9
Longshore, Douglas; Stein, Judith A; Conner, Bradley T (2004) Psychosocial antecedents of injection risk reduction: a multivariate analysis. AIDS Educ Prev 16:353-66
Longshore, D; Annon, J; Anglin, M D (1998) Long-term trends in self-reported HIV risk behavior: injection drug users in Los Angeles, 1987 through 1995. J Acquir Immune Defic Syndr Hum Retrovirol 18:64-72