Cigarette use and nicotine dependence are currently considered among the most pressing public health problems worldwide. Smoking is the leading cause of preventable death in the United States and the single most important avoidable cause of morbidity and premature mortality worldwide. Unlike other mental disorders (e.g., schizophrenia), the onset and chronicity of nicotine dependence could be largely prevented or diminished. It is accepted that genetic and environmental factors play a role in nicotine dependence, yet factors identified to date do not seem to completely explain this epidemic in scope or intractability. Recent evidence strongly suggests the importance of comorbid psychopathology in the onset and persistence of nicotine dependence. The overarching goal of this project is therefore to examine the relationship between anxiety disorders and depression and nicotine dependence, to examine potential mechanisms of this association, and to determine the extent to which it is generalizable to various understudied segments of the adult population. This investigation has two main Specific Aims:
Aim 1 : To examine the influence of anxiety disorders and depression on the onset, course, persistence, morbidity, and offset of nicotine dependence among adults in the community.
Aim 2 : To determine possible mechanisms of the association between anxiety disorders and depression and nicotine dependence among adults in the community (e.g., does parental psychopathology increase vulnerability to both depression and nicotine dependence). While the prevalence of cigarette smoking has declined over the past several decades, this decline has not been equal across all segments of the population and nicotine dependence has not declined as universally. Despite available information on the health risks associated with cigarette use, adults continue to initiate smoking and continue smoking, especially vulnerable segments of the population, including as females and young adults. Information gained from the proposed investigation would allow us to develop better intervention programs using existing psychiatric treatment tools aimed to reduce onset and persistence of cigarette use and nicotine dependence through both primary and secondary prevention of anxiety disorders and depression. Use of the NESARC offers a unique opportunity to analyze a large, longitudinal, epidemiologic dataset.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA020892-04
Application #
7474026
Study Section
Special Emphasis Panel (ZDA1-MXS-M (20))
Program Officer
Wideroff, Louise
Project Start
2005-09-30
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2011-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$261,807
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Pacek, Lauren R; Copeland, Jan; Dierker, Lisa et al. (2018) Among whom is cigarette smoking declining in the United States? The impact of cannabis use status, 2002-2015. Drug Alcohol Depend 191:355-360
Weinberger, Andrea H; Gbedemah, Misato; Wall, Melanie M et al. (2018) Cigarette use is increasing among people with illicit substance use disorders in the United States, 2002-14: emerging disparities in vulnerable populations. Addiction 113:719-728
Moeller, Scott J; Fink, David S; Gbedemah, Misato et al. (2018) Trends in Illicit Drug Use Among Smokers and Nonsmokers in the United States, 2002-2014. J Clin Psychiatry 79:
Goodwin, Renee D; Pacek, Lauren R; Copeland, Jan et al. (2018) Trends in Daily Cannabis Use Among Cigarette Smokers: United States, 2002-2014. Am J Public Health 108:137-142
Weinberger, Andrea H; Platt, Jonathan; Esan, Hannah et al. (2017) Cigarette Smoking Is Associated With Increased Risk of Substance Use Disorder Relapse: A Nationally Representative, Prospective Longitudinal Investigation. J Clin Psychiatry 78:e152-e160
Goodwin, Renee D; Wall, Melanie M; Garey, Lorra et al. (2017) Depression among current, former, and never smokers from 2005 to 2013: The hidden role of disparities in depression in the ongoing tobacco epidemic. Drug Alcohol Depend 173:191-199
Weinberger, Andrea H; Kashan, Rachel S; Shpigel, Danielle M et al. (2017) Depression and cigarette smoking behavior: A critical review of population-based studies. Am J Drug Alcohol Abuse 43:416-431
Weinberger, Andrea H; Gbedemah, Misato; Goodwin, Renee D (2017) Cigarette smoking quit rates among adults with and without alcohol use disorders and heavy alcohol use, 2002-2015: A representative sample of the United States population. Drug Alcohol Depend 180:204-207
Goodwin, Renee D; Cheslack-Postava, Keely; Nelson, Deborah B et al. (2017) Smoking during pregnancy in the United States, 2005-2014: The role of depression. Drug Alcohol Depend 179:159-166
Weinberger, Andrea H; Platt, Jonathan; Goodwin, Renee D (2016) Is cannabis use associated with an increased risk of onset and persistence of alcohol use disorders? A three-year prospective study among adults in the United States. Drug Alcohol Depend 161:363-7

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