This project examines the intermediate neural systems that mediate the gene-behavior relationships involv- ed in risk for development of substance use disorders (SUDs) with special focus on alcohol, cannabis, and nicotine. We will characterize this circuitry, study its interaction with two intermediate behavioral phenotypes (behavioral undercontrol and negative affectivity), and examine the contribution of selected genetic variants, and early-life stress on the neural correlates of impulsivity and negative emotionality in children with varying risk for development of SUDs in adulthood [G2 sample of the Michigan Longitudinal Study(MLS)]. We will examine these correlates during childhood and begin to characterize changes that occur during adolesc- ence. The general hypothesis is that dysregulation of the brain networks involved in processing and regula- tion of behavior and affect during childhood underlies a heightened predisposition to develop SUDs at a later age. Both behavioral undercontrol and affective dysregulation at an early age are strong predictors of SUDs later in life, and these processes are regulated by complex neuronal circuits. We will use fMRI to investigate these neural systems in a sample of 8-10 year old boys &girls (n=129) from the ongoing MLS in a longitud- inal design in which scanning occurs at 2-year intervals. It is expected that children at high risk for develop- ment of SUDs based on the risk conferred by behavioral phenotypes (measured initially as externalizing and internalizing behavior and later by developmental trajectory classes), will demonstrate alterations in the functional responses of neuronal circuitry involved in impulse control and emotional regulation. It is also ex- pected that this effect will be modified by genes and early-life stress. Changes in brain functional responses over time are expected to be influenced by risk conferred by genetic variants and early stress. As models of gene-trait-environment interaction over time are developed in the MLS, we will investigate the relationship between brain responses and these developmental phenotypes. As substance abuse problems develop in this sample, this information will be available during subsequent funding periods to determine dysfunctions in neural circuitry associated with the early development of SUDs during adolescence.

Public Health Relevance

This project will provide in-depth understanding about the intermediate neural pathways underlying susceptibility to drug use disorders, their genetic basis, and the possible interactive role of the social environment in producing variations in risk over time. Findings will have direct implications for early identific- ation, prevention, and early treatment of at-risk individuals as well as those in early stages of drug addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA027261-04
Application #
8246493
Study Section
Special Emphasis Panel (ZDA1-RXL-E (02))
Program Officer
Sirocco, Karen
Project Start
2009-04-15
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$785,594
Indirect Cost
$277,119
Name
University of Michigan Ann Arbor
Department
Psychiatry
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Fava, Nicole M; Trucco, Elisa M; Martz, Meghan E et al. (2018) Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors. Dev Psychopathol :1-12
Martz, Meghan E; Zucker, Robert A; Schulenberg, John E et al. (2018) Psychosocial and neural indicators of resilience among youth with a family history of substance use disorder. Drug Alcohol Depend 185:198-206
Meldrum, Ryan Charles; Trucco, Elisa M; Cope, Lora M et al. (2018) Brain Activity, Low Self-Control, and Delinquency: An fMRI Study of At-Risk Adolescents. J Crim Justice 56:107-117
Trucco, Elisa M; Cope, Lora M; Burmeister, Margit et al. (2018) Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers. J Res Adolesc 28:26-39
Trucco, Elisa M; Villafuerte, Sandra; Hussong, Andrea et al. (2018) Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use. J Abnorm Psychol 127:79-91
Trucco, Elisa M; Villafuerte, Sandra; Burmeister, Margit et al. (2017) Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior. Dev Psychopathol 29:711-724
Hardee, Jillian E; Cope, Lora M; Munier, Emily C et al. (2017) Sex differences in the development of emotion circuitry in adolescents at risk for substance abuse: a longitudinal fMRI study. Soc Cogn Affect Neurosci 12:965-975
Cope, Lora M; Munier, Emily C; Trucco, Elisa M et al. (2017) Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use. Alcohol 59:7-16
Puttler, Leon I; Fitzgerald, Hiram E; Heitzeg, Mary M et al. (2017) BOYS, EARLY RISK FACTORS FOR ALCOHOL PROBLEMS, AND THE DEVELOPMENT OF THE SELF: AN INTERCONNECTED MATRIX. Infant Ment Health J 38:83-96
Martz, Meghan E; Trucco, Elisa M; Cope, Lora M et al. (2016) Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation. JAMA Psychiatry 73:838-44

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