The major objective of the present study is to demonstrate an analgesic response to oral and/or inhaled cannabis in patients with neuropathic low back pain. We will use oral ? 9-THC (dronabinol) and vaporized 3.5% ? 9-THC as active study medications. The primary outcome will be a pain intensity numerical rating scale bordered by 0=no pain and 10=worst possible pain. As a major goal in the development of cannabinoid-based medications is the separation of pain relief from side-effects, numerous other assessments will also be performed. Neuropsychological testing with the Digit Symbol Modalities Test (attention), the Hopkins Verbal Learning Test (learning and memory) and the Grooved Pegboard Test (psychomotor performance) will be performed. In addition, driving simulation will be completed to assess the effect of study medications on this important component of everyday life. Subjective effects will be evaluated with the Marijuana subscale (M-scale) from the Addiction Research Center Inventory to evaluate cannabis intoxication. In addition, questions that include measures of 'high' or 'liking' will be analyzed. The degree of pai relief will then be compared with the adverse consequences of cannabis for a synopsis of the efficacy versus side-effect profile of dronabinol and 3.5% ? 9-THC.

Public Health Relevance

This study will involve treating low back pain associated with nerve injury with oral delta-9-tetrahydrocannabinol (? 9-THC) or whole plant cannabis for eight weeks. Research subjects will consume oral ? 9-THC (dronabinol), vaporized 3.5% ? 9-THC, or placebo. An analysis will then be determined to assess the risk-benefit ratio of dronabinol and vaporized 3.5% ? 9-THC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA038634-02
Application #
9135300
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Lin, Yu
Project Start
2015-09-01
Project End
2019-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093