The primary objective of this project is to determine the prevalence and the ages when progressive and/or delayed onset of sensorineural hearing loss (SNHL) is most likely to occur in infants and young children due to congenital cytomegalovirus (CMV) infection. Our project will also define risk factors in the newborn period that predict SNHL in CMV infected infants without clinically apparent disease.
Our third aim will define the relative contribution of CMV infection to delayed onset hearing loss in the population.
These aims will be achieved by identifying all newborns with congenital CMV infection from University Hospital and serially testing them to evaluate their hearing sensitivity at various ages. Also, two randomly selected control groups of newborns who are CMV negative and pass a newborn auditory screen, one from the risk criteria based screening and the other from the well baby nurseries, will be followed and compared to CMV positive children without hearing loss at birth. All infants born at University Hospital are currently screened virologically for congenital CMV infection by the investigators of this proposal. At 3 weeks, 3, 6, and 12 months of age, each CMV positive infant will have a complete audiological evaluation by a clinical audiologist that will include an auditory brainstem evoked response (ABR) and immittance measures for each ear. Also, each child will have a complete audiological evaluation at 18, 24 and 30 months of age that will include behavioral audiometric assessment (visual reinforcement or play audiometry) and immittance measures to obtain pure tone thresholds, speech reception thresholds and speech discrimination scores. The control groups will receive similar audiological evaluations at 6, 12, and 18 months of age. Our proposal will provide better knowledge of the epidemiology and natural history of SNHL due to CMV. This information is essential for planning early detection and intervention strategies for SNHL in infants and young children.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC002139-02
Application #
2127295
Study Section
Hearing Research Study Section (HAR)
Project Start
1994-07-01
Project End
1999-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Pinninti, Swetha G; Rodgers, Mackenzie D; Novak, Zdenek et al. (2016) Clinical Predictors of Sensorineural Hearing Loss and Cognitive Outcome in Infants with Symptomatic Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 35:924-6
Dreher, A Mackenzie; Arora, Nitin; Fowler, Karen B et al. (2014) Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 164:855-9
Boppana, Suresh B; Ross, Shannon A; Fowler, Karen B (2013) Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis 57 Suppl 4:S178-81
Fowler, Karen B (2013) Congenital cytomegalovirus infection: audiologic outcome. Clin Infect Dis 57 Suppl 4:S182-4
Rosenthal, Lauren Stancik; Fowler, Karen B; Boppana, Suresh B et al. (2009) Cytomegalovirus shedding and delayed sensorineural hearing loss: results from longitudinal follow-up of children with congenital infection. Pediatr Infect Dis J 28:515-20
Ross, Shannon A; Novak, Zdenek; Fowler, Karen B et al. (2009) Cytomegalovirus blood viral load and hearing loss in young children with congenital infection. Pediatr Infect Dis J 28:588-92
Ross, Shannon A; Novak, Zdenek; Kumbla, Rekha A et al. (2007) GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. Pediatr Res 61:687-91
Ross, Shannon A; Fowler, Karen B; Ashrith, Guha et al. (2006) Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. J Pediatr 148:332-6
Fowler, Karen B; Boppana, Suresh B (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226-31
Fowler, Karen B; Pass, Robert F (2006) Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity. Pediatrics 118:e286-92

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