Abstract

The overall goals of this project are to (1) obtain behavioral estimates of tinnitus induced by salicylate and acoustic overstimulation and measure the time course and the pitch of the tinnitus in individual animals, (2) identify the changes in neural activity (single unit activity, local field potentials) in the auditory cortex of awake rats using16 channel recording electrodes and (3) determine how the time course and pattern of neural activity correlate with behavioral measures of the pitch and time course of tinnitus, (4) determine if the behavioral and neurophysiological measures of salicylate induced tinnitus and noise-induced tinnitus can be suppressed by NS1883, a potassium channel agonist that has shown promise in suppressing salicylate-induced tinnitus. Two behavioral techniques, SIPAC and GPIAS, will be used to independently confirm the time course and pitch of the tinnitus. Spontaneous and sound evoked neural activity will be assessed in awake animals using chronically implanted 16-channel electrode arrays. The project will significantly advance our understanding of the time course and pitch of noise and drug induced tinnitus in an animal model, aid in identifying the key neurophysiological changes in the auditory cortex that are associated with tinnitus, and evaluate the effectiveness of a potassium channel agonist in suppressing salicylate and noise-induced tinnitus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC009219-04
Application #
8033713
Study Section
Auditory System Study Section (AUD)
Program Officer
Miller, Roger
Project Start
2008-03-01
Project End
2013-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
4
Fiscal Year
2011
Total Cost
$322,774
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Chen, G-D; Sheppard, A; Salvi, R (2016) Noise trauma induced plastic changes in brain regions outside the classical auditory pathway. Neuroscience 315:228-45
Hinduja, Sneha; Kraus, Kari Suzanne; Manohar, Senthilvelan et al. (2015) D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res 27:199-204
Liu, Hong; Ding, Dalian; Sun, Hong et al. (2014) Cadmium-induced ototoxicity in rat cochlear organotypic cultures. Neurotox Res 26:179-89
Chen, Guang-Di; Radziwon, Kelly E; Kashanian, Nina et al. (2014) Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats. Neural Plast 2014:658741
Ralli, M; Troiani, D; Podda, M V et al. (2014) The effect of the NMDA channel blocker memantine on salicylate-induced tinnitus in rats. Acta Otorhinolaryngol Ital 34:198-204
Deng, Lili; Ding, Dalian; Su, Jiping et al. (2013) Salicylate selectively kills cochlear spiral ganglion neurons by paradoxically up-regulating superoxide. Neurotox Res 24:307-19
Stolzberg, Daniel; Hayes, Sarah H; Kashanian, Nina et al. (2013) A novel behavioral assay for the assessment of acute tinnitus in rats optimized for simultaneous recording of oscillatory neural activity. J Neurosci Methods 219:224-32
Kraus, K S; Ding, D; Jiang, H et al. (2013) Up-regulation of GAP-43 in the chinchilla ventral cochlear nucleus after carboplatin-induced hearing loss: correlations with inner hair cell loss and outer hair cell loss. Hear Res 302:74-82
Campolo, Jennifer; Lobarinas, Edward; Salvi, Richard (2013) Does tinnitus ""fill in"" the silent gaps? Noise Health 15:398-405
Chen, Guang-Di; Stolzberg, Daniel; Lobarinas, Edward et al. (2013) Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus. Hear Res 295:100-13

Showing the most recent 10 out of 33 publications