This proposal seeks to develop a clinically useful artificial oral mucosa. Covering epithelial and connective tissue defects in the oral cavity is a problem, in preprosthetic, periodontal, and cancer surgery, in which special demands are made on the function and quality of the graft. Current methods of providing mucosal substitutes are inadequate. A recently developed collagen-glycosaminoglycan membrane will be tested as an artificial mucosa. Results will be evaluated using histologic and wound size determinations.
| Cianciarulo, F L; Phillips, P D; Cristofalo, V J (1993) Effects of tumor necrosis factor and interferon-beta on proliferation and epidermal growth factor binding in young and senescent WI-38 cells. In Vitro Cell Dev Biol Anim 29A:656-60 |
| Bertolami, C N; Ellis, D G; Donoff, R B (1988) Healing of cutaneous and mucosal wounds grafted with collagen-glycosaminoglycan/silastic bilayer membranes: a preliminary report. J Oral Maxillofac Surg 46:971-8 |
