Infection with human papilomavirus (HPV) is causitive in the development of greater than 95% of cervical cancers and in other genital cancers. Recent evidence suggest that maligant tumors in the oral cavity also are associated with similar oncogenic HPV types. Studies further suggest that HPV may be causative in a subset of oral caner patients. The purpose of this study is to characterize the source of HPV transmission to the oral cavity and whether the virus may be a marker of early and greater susceptibility to oral cancer. HPV infection is thought to be not only sexually transmitted primarily between adults, but preliminary studies suggest that HPV may be is transmitted vertically during parturition from maternal cervical secretions to the oral cavity of her newborn. However, the frequency with which this mode, compared with the sexual mode, of transmission occurs is currently unclear. Thus maternal HPV infection may be associated with an increased prevalence of HPV i their newborns which subsequently could increase the offspring risk to oral cancer when they are adults. In this molecular epidemiology project we propose to examine the prevalence of vertical transmission of cervical HPV infection from pregnant women to the oral cavity of their newborns. Maternal cervical and oral specimens will be compared with their newborns for HPV DNA after birth, and at 1 week and 6 months follow-up to verify viral infection. To further verify the route of transmission, DNA sequencing of type specific HPV+maternal/newborn samples will be performed. Likewise paternal orals specimens will be collected and similar HPV types will be sequenced. The study also will characterize the prevalence of HPV in the oral cavity in a cross-section of youth between ages 1-20 for whom no data exist. Their prevalence rates will be compared to that in newborns to characterized changes in prevalence from birth to early adulthood in conjunction with information regarding potential acquisition of viral infection. The study will enhanced our knowledge about how HPV is transmitted to the oral cavity. This is important to determine since the evidence is mounting that HPV is causative in the development of oral cancer. The findings would provide information regarding the age at which one becomes a carrier of the virus and suggest whom to target for prevention of exposure,or early screening and vaccination against the virus before the onset of cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE011979-03
Application #
2882724
Study Section
Special Emphasis Panel (ZRG4-OBM-1 (03))
Project Start
1997-05-01
Project End
2001-02-28
Budget Start
1999-03-01
Budget End
2000-02-29
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Iowa
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Toporcov, Tatiana Natasha; Znaor, Ariana; Zhang, Zuo-Feng et al. (2015) Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. Int J Epidemiol 44:169-85
Conway, David I; Brenner, Darren R; McMahon, Alex D et al. (2015) Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. Int J Cancer 136:1125-39
Heck, Julia E; Berthiller, Julien; Vaccarella, Salvatore et al. (2010) Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol 39:166-81
Smith, Elaine M; Parker, Michael A; Rubenstein, Linda M et al. (2010) Evidence for vertical transmission of HPV from mothers to infants. Infect Dis Obstet Gynecol 2010:326369
Gaudet, Mia M; Olshan, Andrew F; Chuang, Shu-Chun et al. (2010) Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Int J Epidemiol 39:1091-102
Smith, Elaine M; Pawlita, Michael; Rubenstein, Linda M et al. (2010) Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer. Int J Cancer 127:111-7
Hashibe, Mia; Brennan, Paul; Chuang, Shu-Chun et al. (2009) Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 18:541-50
Smith, Elaine M; Wang, Donghong; Rubenstein, Linda M et al. (2008) Association between p53 and human papillomavirus in head and neck cancer survival. Cancer Epidemiol Biomarkers Prev 17:421-7
Smith, Elaine M; Wang, Donghong; Kim, Yoonsang et al. (2008) P16INK4a expression, human papillomavirus, and survival in head and neck cancer. Oral Oncol 44:133-42
Hashibe, Mia; Brennan, Paul; Benhamou, Simone et al. (2007) Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst 99:777-89

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