Biomineralization processes such as formation of bones and teeth require controlled mineral deposition and self-assembly into hierarchical biocomposites with unique mechanical properties. Ideal biomaterials for regeneration and repair of intramembranous and endochondral bone must be biocompatible, an optimal template for vascular invasion, facilitate normal differentiation of osteoprogenitor cells, ideal for deposition of mineral and possess intrinsic biocompatible properties. Novel methods of designing tissue repair and restoration materials using bioinspired strategies are currently in vogue. Therefore, it is possible that hierarchically organized nanomaterials can be constructed by tailor-made peptide sequences with self-assembling properties. Our overall goal is to employ novel strategies for fabrication of biomaterial for bone repair with a three-dimensional microstructure, by incorporating peptides with self-assembly characteristics along with spatial presentation of bioactive ligands that would provide a physiological environment for cells, facilitating proliferation, differentiation and inducing mineralized tissue formation. Specifically we will: (1) Design and fabricate self-assembled matrices that contain motifs for self-assembly, cell-adhesion and mineral induction; (2) Test the functionality's of the motifs incorporated in the scaffold (3) Test the osteogenic activity of the scaffold in vivo.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE016533-04
Application #
7218004
Study Section
Skeletal Biology Development and Disease Study Section (SBDD)
Program Officer
Lumelsky, Nadya L
Project Start
2004-07-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2009-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$309,014
Indirect Cost
Name
University of Illinois at Chicago
Department
Dentistry
Type
Schools of Dentistry
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
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