Respiratory organs experience repetitive and wide-ranging mechanical forces during respiration. These mechanical forces within the airway are thought to serve as cues to trigger physiological responses. Yet, the respiratory function of mechanotransduction is not well established, partly due to our inability to selectively modulate mechanotransduction. We recently reported that Piezo2, a mechanically activated cation channel, is the principal mechanotransducer in low threshold cutaneous mechanoreceptors and skeletal muscle-innervating proprioceptors in mice. Based on its function as a mechanotransducer, its abundance in various populations of sensory neurons, and preliminary data presented here, we will explore the role of mechanotransduction in respiratory function using Piezo-deficient and Piezo-gain-of-function mouse models.
Respiratory dysfunction is a notorious cause of perinatal mortality in infants and of sleep apnea (temporary cessation of breathing) in adults, and yet the mechanisms of respiratory control are not clearly established. Gain of function mutations in mechanically activated Piezo2 ion channels in humans cause arthrogryposis with restrictive lung disease. Here, we will explore the role of Piezo ion channel in respiratory control.
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