Our parent grant has been awarded for studying HIV associated human oral mucosal immune dysfunction using in vitro HIV tonsil cell system (Aim 1-parent grant) and HIV+ patient derived cells (Aim 2-parent grant). Our current proposal involves a new aim where we hypothesize that oral immune cell dysregulation that we observed in HIV+ patients might correlate with metabolite changes in saliva derived from HIV+ patients. This sub-project, in the context of the parent grant will lead to new ways of thinking about oral inflammation in HIV+ individuals, and aid in generating novel therapeutic strategies to manage HIV mediated chronic inflammation and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
3R01DE026923-04S1
Application #
10067125
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
Iida, Hiroko
Project Start
2017-04-01
Project End
2021-01-31
Budget Start
2020-08-26
Budget End
2021-01-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106