Abstract

The research to be carried out will be in three main categories relating to corticotrophin-releasing factor (CRF), in general neuroendocrinology, and thyroid physiology and disease. CRF in the hypothalamus and neurohypophysis of various species and strains will be compared. The in vivo activity of CRF-A (approximately 100,000 daltons) and CRF-B (approximately 10,000-15,000 daltons) will be evaluated. Various studies related to neuroendocrine regulation of ACTH, TSH, and prolactin will be performed. The pathogenesis of lymphoid thyroiditis, process of thyroid secretion, and treatment of Graves' disease will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK001447-30S1
Application #
3224307
Study Section
Endocrinology Study Section (END)
Project Start
1976-04-01
Project End
1987-03-31
Budget Start
1986-08-01
Budget End
1987-03-31
Support Year
30
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Wang, X; Greer, M A (1995) Blocking K+ channels with TEA induces plasmalemma depolarization, increased [Ca2+]i, and ACTH secretion in AtT-20 cells. Mol Cell Endocrinol 109:11-8
Sato, N; Wang, X; Greer, M A (1994) Comparison of ramp and square-wave exposure to thyrotrophin-releasing hormone or depolarizing K+ on cytosolic Ca2+ concentration and prolactin secretion in GH4C1 cells. J Endocrinol 142:145-52
Wang, X; Inukai, T; Greer, M A et al. (1994) Rat Prl and TSH secretion are regulated differently by K(+)-channel blockers. Am J Physiol 266:E39-43
Wang, X; Chik, C L; Ho, A K et al. (1993) Cyclic adenosine monophosphate is not part of the transduction chain by which cell-swelling induces secretion in either normal or tumor-derived GH4C1 pituitary cells. Metabolism 42:435-9
Greer, M A; Sato, N; Wang, X et al. (1993) Evidence that the major physiological role of TRH in the hypothalamic paraventricular nuclei may be to regulate the set-point for thyroid hormone negative feedback on the pituitary thyrotroph. Neuroendocrinology 57:569-75
Inukai, T; Wang, X; Greer, M A et al. (1993) Isotonic but not hypertonic ethanol stimulates LHRH secretion from perifused rat median eminence. Neuroendocrinology 58:258-62
Inukai, T; Wang, X; Greer, S E et al. (1993) Adenosine 3',5'-cyclic monophosphate-mediated prolactin secretion in GH4C1 cells involves Ca2+ influx through L-type Ca2+ channels. Cell Calcium 14:219-26
Wang, X; Inukai, T; Greer, M A (1993) Tetraethylammonium blockade of K+ channels in GH4C1 cells regulates prolactin secretion by inducing Ca2+ influx. Cell Calcium 14:573-80
Sato, N; Wang, X; Greer, M A (1992) Protein kinase C modulates cell swelling-induced Ca2+ influx and prolactin secretion in GH4C1 cells. Mol Cell Endocrinol 86:137-42
Wang, X B; Sato, N; Greer, M A (1992) Medium hyperosmolarity inhibits prolactin secretion induced by depolarizing K+ in GH4C1 cells by blocking Ca2+ influx. Mol Cell Endocrinol 83:79-84

Showing the most recent 10 out of 41 publications