Abstract

The enzymes involved in iodothyronine metabolism in liver, brain, and pituitary will be purified and their actions analyzed. Regulation of iodothyronine deiodinase activity in liver, brain, adenohypophysis, and pineal by hormones and various neural influences will be investigated. We will investigate control mechanisms regulating the nyctohemeral rhythm of Type-II 5'-deiodinase which we have discovered in pineal and adenohypophysis and evaluate its possible physiologic role.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK001447-34
Application #
3224310
Study Section
Endocrinology Study Section (END)
Project Start
1976-04-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
34
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Wang, X; Greer, M A (1995) Blocking K+ channels with TEA induces plasmalemma depolarization, increased [Ca2+]i, and ACTH secretion in AtT-20 cells. Mol Cell Endocrinol 109:11-8
Sato, N; Wang, X; Greer, M A (1994) Comparison of ramp and square-wave exposure to thyrotrophin-releasing hormone or depolarizing K+ on cytosolic Ca2+ concentration and prolactin secretion in GH4C1 cells. J Endocrinol 142:145-52
Wang, X; Inukai, T; Greer, M A et al. (1994) Rat Prl and TSH secretion are regulated differently by K(+)-channel blockers. Am J Physiol 266:E39-43
Wang, X; Chik, C L; Ho, A K et al. (1993) Cyclic adenosine monophosphate is not part of the transduction chain by which cell-swelling induces secretion in either normal or tumor-derived GH4C1 pituitary cells. Metabolism 42:435-9
Greer, M A; Sato, N; Wang, X et al. (1993) Evidence that the major physiological role of TRH in the hypothalamic paraventricular nuclei may be to regulate the set-point for thyroid hormone negative feedback on the pituitary thyrotroph. Neuroendocrinology 57:569-75
Inukai, T; Wang, X; Greer, M A et al. (1993) Isotonic but not hypertonic ethanol stimulates LHRH secretion from perifused rat median eminence. Neuroendocrinology 58:258-62
Inukai, T; Wang, X; Greer, S E et al. (1993) Adenosine 3',5'-cyclic monophosphate-mediated prolactin secretion in GH4C1 cells involves Ca2+ influx through L-type Ca2+ channels. Cell Calcium 14:219-26
Wang, X; Inukai, T; Greer, M A (1993) Tetraethylammonium blockade of K+ channels in GH4C1 cells regulates prolactin secretion by inducing Ca2+ influx. Cell Calcium 14:573-80
Inukai, T; Wang, X; Greer, M A (1992) Alpha-adrenergic inhibition of thyrotropin-releasing hormone-induced prolactin secretion in GH4C1 cells is associated with a depressed rise in intracellular Ca2+. Mol Cell Endocrinol 87:29-34
Sato, N; Wang, X; Greer, M A (1992) An acute release of Ca2+ from sequestered intracellular pools is not the primary transduction mechanism causing the initial burst of PRL and TSH secretion induced by TRH in normal rat pituitary cells. Cell Calcium 13:173-82

Showing the most recent 10 out of 41 publications