Studies on the hemeproteins, hemoglobin, myoglobin, catalase, peroxidase and cytochrome P-450 will be carried out in order to determine the mechanisms of action of oxygen storage, transport and activation and the mechanisms of electron transport. These enzymes and simple metalloporphyrins will be studied using electrochemical, kinetic, optical and magnetic resonance techniques. The goals are an understanding of the structural and electronic effects which govern the proper functioning of these proteins, as well as the causes and effects of their misfunctioning such as with abnormal hemoglobins and heptatic destruction of P-450 by unsaturated xenobiotics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK017989-12
Application #
3225901
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1979-03-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
12
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of British Columbia
Department
Type
DUNS #
800772162
City
Vancouver
State
BC
Country
Canada
Zip Code
V6 1Z3