Studies on the hemeproteins, hemoglobins, myoglobin, catalase, peroxidase and cytochrome P-450 will be carried out in order to determine the mechanism of action of oxygen storage, transport and activation and the mechanisms of electron transport. These enzymes and simple metal- loporphyrins will be studied using electrochemical, kinetic, optical and magnetic resonance techniques. The goals are an understanding of the structural and electronic effects which govern the proper functioning of these proteins. Various dimeric porphyrins have been prepared to answer these questions and another series of dimeric porphyrins will be prepared to answer these questions and another series of dimeric porphyrins will be prepared for use in photodynamic therapy treatment of cancer. Water soluble hemes, capable or reversibly binding dioxygen will be studied as possible blood substitutes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK017989-15
Application #
3225903
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1979-03-01
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
15
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of British Columbia
Department
Type
DUNS #
800772162
City
Vancouver
State
BC
Country
Canada
Zip Code
V6 1-Z3