This research is designed to investigate nutritionally-induced alterations in hormones and their impact on the-nutritional requirements of humans. It is specifically designed to investigate the effects of energy_balance and imbalance and diet composition on thyroid hormone and catecholamine metabolism, and how thermogenesis (energy expenditure) is regulated. A new hypothesis is proposed to explain how thyroid hormone metabolism and sympathetic nervous system activity are regulated by energy balance and caloric flux. Nutritionally-induced alterations in hormones and sympathetic nervous system activity will be correlated with changes in thermogenesis to assess their role(s) in the adaptation of the thermogenic response to altered nutritional states and whether obesity results from a defect(s) in these adaptive responses. In vivo and in vitro estimates of muscle Na+, K+-ATPase activity will be correlated with nutritionally-induced alterations in thermogenesis, plasma thyroid hormone and norepinephrine metabolism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK018535-11
Application #
3226083
Study Section
Endocrinology Study Section (END)
Project Start
1978-05-01
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
11
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
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Poehlman, E T; McAuliffe, T; Danforth Jr, E (1990) Effects of age and level of physical activity on plasma norepinephrine kinetics. Am J Physiol 258:E256-62

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