These studies will explore the biologic role of the mesangium with respect to the uptake and disposal of macromolecules. This will include an analysis of the role of electrostatic charge of macromolecules such as ferritin and immune complexes made with ferritin and albumin of different isoelectric points. These studies will be correlated with studies of the mononuclear phagocytic system. The afferent and efferent mesangial limbs will be further defined by studies using these probes in experimental renal disease.
| Kleppel, M M; Michael, A F (1990) Expression of novel basement membrane components in the developing human kidney and eye. Am J Anat 187:165-74 |
| Kleppel, M M; Kashtan, C; Santi, P A et al. (1989) Distribution of familial nephritis antigen in normal tissue and renal basement membranes of patients with homozygous and heterozygous Alport familial nephritis. Relationship of familial nephritis and Goodpasture antigens to novel collagen chains and type Lab Invest 61:278-89 |
| Kleppel, M M; Santi, P A; Cameron, J D et al. (1989) Human tissue distribution of novel basement membrane collagen. Am J Pathol 134:813-25 |
| Kashtan, C E; Atkin, C L; Gregory, M C et al. (1989) Identification of variant Alport phenotypes using an Alport-specific antibody probe. Kidney Int 36:669-74 |
