These studies will explore the biologic role of the mesangium with respect to the uptake and disposal of macromolecules. This will include an analysis of the role of electrostatic charge of macromolecules such as ferritin and immune complexes made with ferritin and albumin of different isoelectric points. These studies will be correlated with studies of the mononuclear phagocytic system. The afferent and efferent mesangial limbs will be further defined by studies using these probes in experimental renal disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK025518-09
Application #
3227444
Study Section
Pathology A Study Section (PTHA)
Project Start
1979-04-01
Project End
1989-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455