Abstract

A five-year study will be conducted to accomplish the following objectives: (1) To evaluate the linear growth in children with chronic renal failure under treatment with 1,25-dihydroxyvitamin-D3 in a randomized, double-blind, carefully controlled, clinical trial. (2) To assess the long-term efficacy and safety of 1,25-dihydroxyvitamin-D3 therapy in children with chronic renal failure through meticulous comparison to a control group on conventional therapy, with particular attention to the rate of progression of chronic renal failure to ensure that 1,25-dihydroxyvitamin-D3 treatment does not exacerbate the primary disorder. (3) To provide long-term evaluation and follow-up of children with chronic renal insufficiency by means of nutritional biochemical indices and antropometric measurements that will yield information never before collected but urgently needed to reveal the extra-skeletal effects of 1,25-dihydroxyvitamin-D3 treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK031370-05
Application #
3230008
Study Section
(SRC)
Project Start
1983-06-01
Project End
1988-11-30
Budget Start
1987-06-01
Budget End
1988-11-30
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Fremont, Oliver T; Chan, James C M (2012) Understanding Bartter syndrome and Gitelman syndrome. World J Pediatr 8:25-30
Yi, Z W; Rodriguez, G E; Krieg Jr, R J et al. (1996) Rat macrophages in experimental IgA nephropathy. Biochem Mol Med 57:152-5
Foreman, J W; Abitbol, C L; Trachtman, H et al. (1996) Nutritional intake in children with renal insufficiency: a report of the growth failure in children with renal diseases study. J Am Coll Nutr 15:579-85
Krieg Jr, R J; Latta, K; Niimi, K et al. (1995) Impact of uraemia on food efficiency and the pulsatile mode of growth hormone secretion in rats. J Endocrinol 146:509-17
Krieg Jr, R J; Santos, F; Chan, J C (1995) Growth hormone, insulin-like growth factor and the kidney. Kidney Int 48:321-36
Trachtman, H; Chan, J C; Boyle, R et al. (1995) The relationship between calcium, phosphorus, and sodium intake, race, and blood pressure in children with renal insufficiency: a report of the Growth Failure in Children with Renal Diseases (GFRD) Study. J Am Soc Nephrol 6:126-31
Chan, J C; McEnery, P T; Chinchilli, V M et al. (1994) A prospective, double-blind study of growth failure in children with chronic renal insufficiency and the effectiveness of treatment with calcitriol versus dihydrotachysterol. The Growth Failure in Children with Renal Diseases Investigators. J Pediatr 124:520-8
Pandak, W M; Vlahcevic, Z R; Heuman, D M et al. (1994) Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rats with subtotal nephrectomy. Kidney Int 46:358-64
Thabet, M A; Challa, A; Chan, W et al. (1994) Insulin-like growth factor and growth hormone receptor in nephrotic rats. Am J Physiol 266:E102-6
Boyle, R M; Chinchilli, V M; Shasky, D A (1993) Masking of physicians in the Growth Failure in Children with Renal Diseases Clinical Trial. Pediatr Nephrol 7:204-6

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