Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037016-08
Application #
2139939
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1987-05-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Nakayama, J; Fukuda, M N; Hirabayashi, Y et al. (1996) Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. J Biol Chem 271:3684-91
Misago, M; Liao, Y F; Kudo, S et al. (1995) Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. Proc Natl Acad Sci U S A 92:11766-70
Yamaguchi, N; Fukuda, M N (1995) Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. J Biol Chem 270:12170-6
Nakayama, J; Fukuda, M N; Fredette, B et al. (1995) Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. Proc Natl Acad Sci U S A 92:7031-5
Fukuda, M N; Sato, T; Nakayama, J et al. (1995) Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev 9:1199-210
Aoki, D; Lee, N; Yamaguchi, N et al. (1992) Golgi retention of a trans-Golgi membrane protein, galactosyltransferase, requires cysteine and histidine residues within the membrane-anchoring domain. Proc Natl Acad Sci U S A 89:4319-23
Fukuda, M N; Gaetani, G F; Izzo, P et al. (1992) Incompletely processed N-glycans of serum glycoproteins in congenital dyserythropoietic anaemia type II (HEMPAS). Br J Haematol 82:745-52
Wang, W C; Lee, N; Aoki, D et al. (1991) The poly-N-acetyllactosamines attached to lysosomal membrane glycoproteins are increased by the prolonged association with the Golgi complex. J Biol Chem 266:23185-90
Fukuda, M N; Masri, K A; Dell, A et al. (1990) Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II. Proc Natl Acad Sci U S A 87:7443-7
Aoki, D; Appert, H E; Johnson, D et al. (1990) Analysis of the substrate binding sites of human galactosyltransferase by protein engineering. EMBO J 9:3171-8

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