Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK038925-09
Application #
2140724
Study Section
Toxicology Subcommittee 2 (TOX)
Program Officer
Scherbenske, M James
Project Start
1988-04-01
Project End
1997-12-31
Budget Start
1996-04-01
Budget End
1997-12-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Adirondack Biomedical Research Institute
Department
Type
DUNS #
City
Lake Placid
State
NY
Country
United States
Zip Code
12946
Chen, Q; Jones, T W; Stevens, J L (1994) Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates. J Cell Physiol 161:293-302
Yu, K; Chen, Q; Liu, H et al. (1994) Signalling the molecular stress response to nephrotoxic and mutagenic cysteine conjugates: differential roles for protein synthesis and calcium in the induction of c-fos and c-myc mRNA in LLC-PK1 cells. J Cell Physiol 161:303-11
Zhang, G; Ichimura, T; Maier, J A et al. (1993) A role for fibroblast growth factor type-1 in nephrogenic repair. Autocrine expression in rat kidney proximal tubule epithelial cells in vitro and in the regenerating epithelium following nephrotoxic damage by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine in vi J Biol Chem 268:11542-7
Bruschi, S A; West, K A; Crabb, J W et al. (1993) Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity. J Biol Chem 268:23157-61
Fisher, M B; Hayden, P J; Bruschi, S A et al. (1993) Formation, characterization, and immunoreactivity of lysine thioamide adducts from fluorinated nephrotoxic cysteine conjugates in vitro and in vivo. Chem Res Toxicol 6:223-30
Chen, Q; Yu, K; Stevens, J L (1992) Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates. J Biol Chem 267:24322-7
Hayden, P J; Welsh, C J; Yang, Y et al. (1992) Formation of mitochondrial phospholipid adducts by nephrotoxic cysteine conjugate metabolites. Chem Res Toxicol 5:232-7
Wallin, A; Zhang, G; Jones, T W et al. (1992) Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells. Lab Invest 66:474-84
Chen, Q; Yu, K; Holbrook, N J et al. (1992) Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol. J Biol Chem 267:8207-12
Chen, Q; Stevens, J L (1991) Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: a role for lipid peroxidation in alkylation induced cytotoxicity. Arch Biochem Biophys 284:422-30

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