Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
9R01DK039044-03
Application #
3238701
Study Section
(SSS)
Project Start
1987-08-01
Project End
1988-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Feke, G T; Buzney, S M; Ogasawara, H et al. (1994) Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci 35:2968-75
Owerbach, D; Gabbay, K H (1994) Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs. Am J Hum Genet 54:909-12
Harrison, D H; Bohren, K M; Ringe, D et al. (1994) An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry 33:2011-20
Bohren, K M; Grimshaw, C E; Lai, C J et al. (1994) Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry 33:2021-32
Bohren, K M; Gabbay, K H (1993) Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity. Adv Exp Med Biol 328:267-77
Wang, K; Bohren, K M; Gabbay, K H (1993) Characterization of the human aldose reductase gene promoter. J Biol Chem 268:16052-8
Bohren, K M; Grimshaw, C E; Gabbay, K H (1992) Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain. J Biol Chem 267:20965-70
Wilson, D K; Bohren, K M; Gabbay, K H et al. (1992) An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science 257:81-4
Bohren, K M; Page, J L; Shankar, R et al. (1991) Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262. J Biol Chem 266:24031-7
Owerbach, D; Gunn, S; Gabbay, K H (1990) Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8. Diabetes 39:1504-9

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