Pharmacological or dietary treatments that perturb calcium metabolism cause rats to ingest large volumes of salt. This project will delineate (1) the physiological basis of this interaction, and (2) the contribution of calcium metabolism to other rodent models of salt intake. Specifically, the involvement of calcium-regulating hormones in the control of salt intake wiLL be assessed by measuring mineral intake and balance in rats with these hormones removed by parathyroidectomy, thyroidectomy, or dietary vitamin D deficiency. In some rats, plasma calcium wiLL be held constant by calcium infusions in order to dissociate any direct effects of calcium-regulating hormones from their effects on plasma calcium. To investigate the relationship between calcium metabolism, salt intake and blood pressure, these variables will be compared in rats treated with calcium blockers, or with genetic hypertension. tHe contribution of calcium to the increase in salt intake associated with reproduction will be studied by examining salt and calcium intake during pregnancy and lactation. Finally, the possible contribution of perturbations in calcium metabolism to the increased salt intake produced by adrenalectomy will be assessed by mineral intake and balance studies. This work will provide a firm foundation for a new rodent model of salt intake, which promises to be directly relevant for understanding excess salt intake and its deleterious consequences in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040099-06
Application #
3240199
Study Section
Biopsychology Study Section (BPO)
Project Start
1988-05-01
Project End
1994-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Monell Chemical Senses Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bachmanov, A A; Schlager, G; Tordoff, M G et al. (1998) Consumption of electrolytes and quinine by mouse strains with different blood pressures. Physiol Behav 64:323-30
Bachmanov, A A; Tordoff, M G; Beauchamp, G K (1998) Voluntary sodium chloride consumption by mice: differences among five inbred strains. Behav Genet 28:117-24
Tordoff, M G (1997) NaCl ingestion ameliorates plasma indexes of calcium deficiency. Am J Physiol 273:R423-32
Tordoff, M G (1997) Polyethylene glycol-induced calcium appetite. Am J Physiol 273:R587-96
Tordoff, M G (1996) Adrenalectomy decreases NaCl intake of rats fed low-calcium diets. Am J Physiol 270:R11-21
Coldwell, S E; Tordoff, M G (1996) Acceptance of minerals and other compounds by calcium-deprived rats: 24-h tests. Am J Physiol 271:R1-10
Okiyama, A; Torii, K; Tordoff, M G (1996) Increased NaCl preference of rats fed low-protein diet. Am J Physiol 270:R1189-96
Tordoff, M G (1996) The importance of calcium in the control of salt intake. Neurosci Biobehav Rev 20:89-99
Tordoff, M G (1996) Effect of chronic ouabain infusion on food, water, and NaCl intake, body composition, and plasma hormones of Sprague-Dawley rats. Physiol Behav 59:87-92
Tordoff, M G; Okiyama, A (1996) Daily rhythm of NaCl intake in rats fed low-Ca2+ diet: relation to plasma and urinary minerals and hormones. Am J Physiol 270:R505-17

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