Abstract

In previous work, the Investigator found that rats deprived of calcium have a robust and very specific appetite for sodium, and that corticosterone (a glucocorticoid hormone) may be an important mediator of the phenomenon. He now proposes characterizing the role of glucocorticoids in sodium appetite. Specific experiments will determine the contribution of corticosterone to the spontaneous sodium intake that occurs under """"""""normal"""""""" conditions; the sodium appetite that occurs on a calcium-deficient diet; and several other paradigms in which high sodium intake is evinced (i.e., during dietary iron or protein deficiency; reproduction; restraint; or treatment with furosemide or angiotensin-II). For each model, corticosterone and/or RU-486 (a corticosterone antagonist) will be given and several behavioral and physiological parameters assessed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040099-10
Application #
2900214
Study Section
Biopsychology Study Section (BPO)
Program Officer
Yanovski, Susan Z
Project Start
1995-07-01
Project End
2000-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Monell Chemical Senses Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Bachmanov, A A; Schlager, G; Tordoff, M G et al. (1998) Consumption of electrolytes and quinine by mouse strains with different blood pressures. Physiol Behav 64:323-30
Bachmanov, A A; Tordoff, M G; Beauchamp, G K (1998) Voluntary sodium chloride consumption by mice: differences among five inbred strains. Behav Genet 28:117-24
Tordoff, M G (1997) NaCl ingestion ameliorates plasma indexes of calcium deficiency. Am J Physiol 273:R423-32
Tordoff, M G (1997) Polyethylene glycol-induced calcium appetite. Am J Physiol 273:R587-96
Tordoff, M G (1996) Adrenalectomy decreases NaCl intake of rats fed low-calcium diets. Am J Physiol 270:R11-21
Coldwell, S E; Tordoff, M G (1996) Acceptance of minerals and other compounds by calcium-deprived rats: 24-h tests. Am J Physiol 271:R1-10
Okiyama, A; Torii, K; Tordoff, M G (1996) Increased NaCl preference of rats fed low-protein diet. Am J Physiol 270:R1189-96
Tordoff, M G (1996) The importance of calcium in the control of salt intake. Neurosci Biobehav Rev 20:89-99
Tordoff, M G (1996) Effect of chronic ouabain infusion on food, water, and NaCl intake, body composition, and plasma hormones of Sprague-Dawley rats. Physiol Behav 59:87-92
Tordoff, M G; Okiyama, A (1996) Daily rhythm of NaCl intake in rats fed low-Ca2+ diet: relation to plasma and urinary minerals and hormones. Am J Physiol 270:R505-17

Showing the most recent 10 out of 22 publications