This project involves the study of erythropoietin-responsive cells, cells that respond to colonystimulating factor, pluripotent hematopoietic stem cells, and the interrelationships among them. Our working hypothesis is that these are essentially the same cells and can be defined by the presence or absence of receptors for the inducers of hematopoietic cell differentiation. We are studying the properties of the erythropoietin receptor of mouse cells and the role of interleukin-3 on the regulation of response to erythropoietin. (M)
| Goldwasser, E; Hermine, O; Pech, N et al. (1994) Internal autocrine regulation of the early stages of hemopoiesis. Ann N Y Acad Sci 718:326-30;discussion 330-3 |
| Pech, N; Hermine, O; Goldwasser, E (1993) Further study of internal autocrine regulation of multipotent hematopoietic cells. Blood 82:1502-6 |
| Hermine, O; Beru, N; Pech, N et al. (1991) An autocrine role for erythropoietin in mouse hematopoietic cell differentiation. Blood 78:2253-60 |
| Goldwasser, E; Pech, N; Ihle, J (1990) Interleukin 3 can compensate for the deficiency in erythroid burst-forming cells in anemic mice of genotype W/Wv. Exp Hematol 18:936-9 |
| Gajewski, T F; Goldwasser, E; Fitch, F W (1988) Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor. J Immunol 141:2635-42 |
