Abstract

. Based on previous studies the investigators propose to perform a placebo-controlled double- blind study to define the role of bacterial overgrowth in children with HIV infection. It is also proposed to further define the molecular nature of HIV and other microbial agents shed in the stools of HIV-infected children with gastrointestinal abnormalities. The ultimate goal of these studies is the development of practical therapeutic regimens for the prevention and treatment of gastrointestinal dysfunction in HIV-infected infants and children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040540-06
Application #
2141375
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1988-07-15
Project End
1996-04-30
Budget Start
1994-05-20
Budget End
1996-04-30
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Ramos-Soriano, A G; Saavedra, J M; Wu, T C et al. (1996) Enteric pathogens associated with gastrointestinal dysfunction in children with HIV infection. Mol Cell Probes 10:67-73
Henderson, R A; Miotti, P G; Saavedra, J M et al. (1996) Longitudinal growth during the first 2 years of life in children born to HIV-infected mothers in Malawi, Africa. Pediatr AIDS HIV Infect 7:91-7
Saavedra, J M; Henderson, R A; Perman, J A et al. (1995) Longitudinal assessment of growth in children born to mothers with human immunodeficiency virus infection. Arch Pediatr Adolesc Med 149:497-502
Henderson, R A; Saavedra, J M (1995) Nutritional considerations and management of the child with human immunodeficiency virus infection. Nutrition 11:121-8
Saavedra, J M; Bauman, N A; Oung, I et al. (1994) Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 344:1046-9
Henderson, R A; Saavedra, J M; Perman, J A et al. (1994) Effect of enteral tube feeding on growth of children with symptomatic human immunodeficiency virus infection. J Pediatr Gastroenterol Nutr 18:429-34
Newburg, D S; Viscidi, R P; Ruff, A et al. (1992) A human milk factor inhibits binding of human immunodeficiency virus to the CD4 receptor. Pediatr Res 31:22-8
Yolken, R H; Li, S; Perman, J et al. (1991) Persistent diarrhea and fecal shedding of retroviral nucleic acids in children infected with human immunodeficiency virus. J Infect Dis 164:61-6
Yolken, R H; Hart, W; Oung, I et al. (1991) Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus. J Pediatr 118:359-63
Yolken, R H; Coutlee, F; Viscidi, R P (1989) New prospects for the diagnosis of viral infections. Yale J Biol Med 62:131-9