Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041765-08
Application #
2141914
Study Section
Endocrinology Study Section (END)
Project Start
1989-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Biophysics
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Yeh, T C; Li, W; Keller, G A et al. (1998) Disruption of a putative SH3 domain and the proline-rich motifs in the 53-kDa substrate of the insulin receptor kinase does not alter its subcellular localization or ability to serve as a substrate. J Cell Biochem 68:139-50
Dandekar, A A; Wallach, B J; Barthel, A et al. (1998) Comparison of the signaling abilities of the cytoplasmic domains of the insulin receptor and the insulin receptor-related receptor in 3T3-L1 adipocytes. Endocrinology 139:3578-84
Yeh, T C; Ogawa, W; Danielsen, A G et al. (1996) Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase. J Biol Chem 271:2921-8
Yamaguchi, T; Fernandez, R; Roth, R A (1995) Comparison of the signaling abilities of the Drosophila and human insulin receptors in mammalian cells. Biochemistry 34:4962-8
Ogawa, W; Hosomi, Y; Roth, R A (1995) Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells. Endocrinology 136:476-81
Liu, F; Roth, R A (1995) Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc Natl Acad Sci U S A 92:10287-91
Ogawa, W; Roth, R A (1994) Characterization of a protein which binds phosphatidylinositol 3,4,5-trisphosphate and 4,5-bisphosphate. Biochim Biophys Acta 1224:533-40
Roth, R A; Liu, F; Chin, J E (1994) Biochemical mechanisms of insulin resistance. Horm Res 41 Suppl 2:51-5
Hosomi, Y; Shii, K; Ogawa, W et al. (1994) Characterization of a 60-kilodalton substrate of the insulin receptor kinase. J Biol Chem 269:11498-502
Ogawa, W; Hosomi, Y; Shii, K et al. (1994) Evidence for two distinct 60-kilodalton substrates of the SRC tyrosine kinase. J Biol Chem 269:29602-8

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