Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043414-04
Application #
2143006
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-05-01
Project End
1998-01-31
Budget Start
1995-05-01
Budget End
1998-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Komar, Anton A; Gross, Stephane R; Barth-Baus, Diane et al. (2005) Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. J Biol Chem 280:15601-11
Constantinou, Constantina; Bushell, Martin; Jeffrey, Ian W et al. (2003) p53-induced inhibition of protein synthesis is independent of apoptosis. Eur J Biochem 270:3122-32
Horton, Lynn E; Bushell, Martin; Barth-Baus, Diane et al. (2002) p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene 21:5325-34
Gelperin, Daniel; Horton, Lynn; DeChant, Anne et al. (2002) Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast. Genetics 161:1453-64
Zoll, Wendy L; Horton, Lynn E; Komar, Anton A et al. (2002) Characterization of mammalian eIF2A and identification of the yeast homolog. J Biol Chem 277:37079-87
Barth-Baus, Diane; Stratton, Carl A; Parrott, Lou et al. (2002) S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells. Nucleic Acids Res 30:1919-28
Gelperin, D; Horton, L; Beckman, J et al. (2001) Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. RNA 7:1268-83
Kroll, S L; Barth-Baus, D; Hensold, J O (2001) The carboxyl-terminal domain of the granulocyte colony-stimulating factor receptor uncouples ribosomal biogenesis from cell cycle progression in differentiating 32D myeloid cells. J Biol Chem 276:49410-8
Richter, N J; Rogers Jr, G W; Hensold, J O et al. (1999) Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. J Biol Chem 274:35415-24
Richter-Cook, N J; Dever, T E; Hensold, J O et al. (1998) Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. J Biol Chem 273:7579-87

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