Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044629-04
Application #
2143945
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-03-01
Project End
1996-11-30
Budget Start
1995-03-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Organized Research Units
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Dillon, Stephanie L; Williamson, Danielle M; Elferich, Johannes et al. (2012) Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol 423:47-62
Thomas, Gary (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3:753-66
Crump, C M; Xiang, Y; Thomas, L et al. (2001) PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO J 20:2191-201
Xiang, Y; Molloy, S S; Thomas, L et al. (2000) The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell 11:1257-73
Molloy, S S; Anderson, E D; Jean, F et al. (1999) Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis. Trends Cell Biol 9:28-35
Molloy, S S; Thomas, L; Kamibayashi, C et al. (1998) Regulation of endosome sorting by a specific PP2A isoform. J Cell Biol 142:1399-411
Jean, F; Stella, K; Thomas, L et al. (1998) alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A 95:7293-8
Wan, L; Molloy, S S; Thomas, L et al. (1998) PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell 94:205-16
Cui, Y; Jean, F; Thomas, G et al. (1998) BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development. EMBO J 17:4735-43
Anderson, E D; VanSlyke, J K; Thulin, C D et al. (1997) Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. EMBO J 16:1508-18

Showing the most recent 10 out of 23 publications