The Massachusetts Male Aging Study (MMAS) is considered a landmark research effort in the fields of aging, urology, and endocrinology. It employs a random sample of community-dwelling men (not a convenience sample of patient volunteers). Its size permits estimation of even relatively rare phenomena (e.g., hypogonadism). It is longitudinal (intra-subject variation) not cross-sectional (inter-subject variation) and has successfully followed a cohort from 987-89 (T1) through 1995-97 (T2). Worldwide, it remains the largest male endocrine database. It is the first and still the only major longitudinal study of ED. It is multidisciplinary. The MMAS team has been extraordinarily productive. Emphasis has been given to the practical clinical applications of scientific findings. The proposed project (""""""""EPIDEMIOLOGY OF HORMONES AND ERECTILE DYSFUNCTION IN AGING MEN"""""""") is designed to extend the highly productive MMAS by following a projected 800 already participating subjects through a third wave (T3). Building directly on earlier work we will: continue investigation of life-span changes in 14 carefully selected hormones in the same subjects; precisely delineate any hypogonadal syndrome and its major correlates; continue pioneering work on erectile dysfunction (ED) and its various predictors; precisely measure the hypothesized relation between ED (sentinel event) and subsequent CVD; extend knowledge concerning ED-related utilization behavior and quality of life in older men; and assess the validity of the single question measure of ED against a clinical urologic examination by a nationally-respected urologist blinded to subjects' self-reported ED status. Methods of data collection will be identical to those used previously for the MMAS. The proposed research will continue to provide the most comprehensive and reliable information available on ED, life-span hormonal changes and their physiological, psychosocial, anthropometric, and behavioral predictors in normally aging men. Prior to the MMAS there was: (a) no well-designed prospective study describing life span changes in endocrine functioning (hormones) in normally aging men; and (b) no definitive population-based study of ED and its biobehavioral correlates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044995-06
Application #
6524144
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Rankin, Tracy L
Project Start
1995-05-19
Project End
2005-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
6
Fiscal Year
2002
Total Cost
$1,161,304
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472
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Araujo, Andre B; Travison, Thomas G; Ganz, Peter et al. (2009) Erectile dysfunction and mortality. J Sex Med 6:2445-54
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Page, Stephanie T; Mohr, Beth A; Link, Carol L et al. (2008) Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study. Asian J Androl 10:193-200
Travison, Thomas G; O'Donnell, Amy B; Araujo, Andre B et al. (2007) Cortisol levels and measures of body composition in middle-aged and older men. Clin Endocrinol (Oxf) 67:71-7
Travison, Thomas G; Araujo, Andre B; Kupelian, Varant et al. (2007) The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 92:549-55

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