Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046379-02
Application #
2145575
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1995-06-01
Project End
1999-05-31
Budget Start
1996-06-27
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Wang, H-Z; Brink, Peter R; Christ, George J (2006) Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances. Am J Physiol Cell Physiol 291:C1366-76
Christ, George J; Day, Nancy S; Day, Michele et al. (2003) Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo. Am J Physiol Regul Integr Comp Physiol 284:R1241-8
Christ, George J (2002) K channels as molecular targets for the treatment of erectile dysfunction. J Androl 23:S10-9
Venkateswarlu, K; Giraldi, A; Zhao, W et al. (2002) Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers. J Urol 168:355-61
Spektor, Mariya; Rodriguez, Ramon; Rosenbaum, Raymond S et al. (2002) Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro. J Urol 167:2628-35
Wang, H Z; Christ, G J (2001) K(ATP) channel currents regulate membrane potential in freshly isolated human and rat bladder smooth muscle cells. Urology 57:110
Melman, A; Christ, G J (2001) Integrative erectile biology. The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction. Urol Clin North Am 28:217-31, vii
Wang, H Z; Day, N; Valcic, M et al. (2001) Intercellular communication in cultured human vascular smooth muscle cells. Am J Physiol Cell Physiol 281:C75-88
Wang, H Z; Lee, S W; Day, N S et al. (2001) Gap junction channel activity in cultured human bladder smooth muscle cell pairs: gating and unitary conductances. Urology 57:111
Huang, H; Petkova, S B; Pestell, R G et al. (2000) Trypanosoma cruzi infection (Chagas' disease) of mice causes activation of the mitogen-activated protein kinase cascade and expression of endothelin-1 in the myocardium. J Cardiovasc Pharmacol 36:S148-50

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