Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047473-04
Application #
2147105
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1993-09-30
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Brown, J A; Chua Jr, S C; Liu, S M et al. (2000) Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. Am J Physiol Regul Integr Comp Physiol 278:R320-30
Schreyer, S A; Chua Jr, S C; LeBoeuf, R C (1998) Obesity and diabetes in TNF-alpha receptor- deficient mice. J Clin Invest 102:402-11
Liu, S M; Leibel, R L; Chua Jr, S C (1998) Partial duplication in the leprdb-Pas mutation is a result of unequal crossing over. Mamm Genome 9:780-1
Chua Jr, S C; Koutras, I K; Han, L et al. (1997) Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45:264-70
Leibel, R L; Chung, W K; Chua Jr, S C (1997) The molecular genetics of rodent single gene obesities. J Biol Chem 272:31937-40
Kahle, E B; Butz, K G; Chua, S C et al. (1997) The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation. Obes Res 5:142-5
Chung, W K; Zheng, M; Chua, M et al. (1997) Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41:332-44
White, D W; Wang, D W; Chua Jr, S C et al. (1997) Constitutive and impaired signaling of leptin receptors containing the Gln --> Pro extracellular domain fatty mutation. Proc Natl Acad Sci U S A 94:10657-62
Chung, W K; Power-Kehoe, L; Chua, M et al. (1997) Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 46:1509-11
Wu-Peng, X S; Chua Jr, S C; Okada, N et al. (1997) Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 46:513-8

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