Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048605-03
Application #
2148990
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Yang, Feng-Chun; Ingram, David A; Chen, Shi et al. (2003) Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest 112:1851-61
Tan, Bai Lin; Yazicioglu, Mustafa N; Ingram, David et al. (2003) Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells. Blood 101:4725-32
Chandra, Saurabh; Kapur, Reuben; Chuzhanova, Nadia et al. (2003) A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype. Blood 102:3548-55
Kapur, Reuben; Chandra, Saurabh; Cooper, Ryan et al. (2002) Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor. Blood 100:1287-93
Gu, Yi; Byrne, Michael C; Paranavitana, Nivanka C et al. (2002) Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Mol Cell Biol 22:7645-57
Kapur, R; Cooper, R; Zhang, L et al. (2001) Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways. Blood 97:1975-81
Ingram, D A; Hiatt, K; King, A J et al. (2001) Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J Exp Med 194:57-69
Gommerman, J L; Sittaro, D; Klebasz, N Z et al. (2000) Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential. Blood 96:3734-42
Yang, F C; Kapur, R; King, A J et al. (2000) Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 12:557-68
Kapur, R; Cooper, R; Xiao, X et al. (1999) The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice. Blood 94:1915-25

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