Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048796-02
Application #
2149253
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Zweier, Christiane; Sticht, Heinrich; Aydin-Yaylagul, Inci et al. (2007) Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet 80:510-7
Wong, Yong Wee; Schulze, Christian; Streichert, Thomas et al. (2007) Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation. Genome Biol 8:R72
Butz, Nataliya V; Gronostajski, Richard M; Campbell, Christine E (2006) T-box proteins differentially activate the expression of the endogenous interferon gamma gene versus transfected reporter genes in non-immune cells. Gene 377:130-9
Butz, Nataliya V; Campbell, Christine E; Gronostajski, Richard M (2004) Differential target gene activation by TBX2 and TBX2VP16: evidence for activation domain-dependent modulation of gene target specificity. Gene 342:67-76
Murtagh, Janice; Martin, Finian; Gronostajski, Richard M (2003) The Nuclear Factor I (NFI) gene family in mammary gland development and function. J Mammary Gland Biol Neoplasia 8:241-54
Carlson, H; Ota, S; Campbell, C E et al. (2001) A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. Hum Mol Genet 10:2403-13
Sinha, S; Abraham, S; Gronostajski, R M et al. (2000) Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene 258:15-29
Seppala, R; Lehto, V P; Gahl, W A (1999) Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme. Am J Hum Genet 64:1563-9
He, M l; Wen, L; Campbell, C E et al. (1999) Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc Natl Acad Sci U S A 96:10212-7
Chaudhry, A Z; Vitullo, A D; Gronostajski, R M (1998) Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters. J Biol Chem 273:18538-46

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