Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049431-03
Application #
2016931
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-09-01
Project End
1998-08-31
Budget Start
1996-09-18
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Urology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Clemow, D B; Steers, W D; Tuttle, J B (2000) Stretch-activated signaling of nerve growth factor secretion in bladder and vascular smooth muscle cells from hypertensive and hyperactive rats. J Cell Physiol 183:289-300
Sherer, T B; Clemow, D B; Tuttle, J B (2000) Calcium homeostasis and nerve growth factor secretion from vascular and bladder smooth muscle cells. Cell Tissue Res 299:201-11
Steers, W D; Clemow, D B; Persson, K et al. (1999) Observations from the spontaneously hypertensive rat. Insight into NGF regulation and noradrenergic hyper-innervation in the lower urinary tract. Adv Exp Med Biol 462:283-92;discussion 311-20
Clemow, D B; Spitsbergen, J M; McCarty, R et al. (1999) Altered NGF regulation may link a genetic predisposition for hypertension with hyperactive voiding. J Urol 161:1372-7
Clemow, D B; Steers, W D; McCarty, R et al. (1998) Altered regulation of bladder nerve growth factor and neurally mediated hyperactive voiding. Am J Physiol 275:R1279-86
Clemow, D B; Tuttle, J B (1998) Effects of growth rate and cell density on nerve growth factor secretion in cultures of vascular and bladder smooth muscle cells from hypertensive and hyperactive rats. Cell Tissue Res 294:431-8
Sherer, T B; Neff, P S; Tuttle, J B (1998) Increased nerve growth factor mRNA stability may underlie elevated nerve growth factor secretion from hypertensive vascular smooth muscle cells. Brain Res Mol Brain Res 62:167-74
Clemow, D B; Spitsbergen, J M; McCarty, R et al. (1998) Arterial nerve growth factor (NGF) mRNA, protein, and vascular smooth muscle cell NGF secretion in hypertensive and hyperactive rats. Exp Cell Res 244:196-205
Spitsbergen, J M; Clemow, D B; McCarty, R et al. (1998) Neurally mediated hyperactive voiding in spontaneously hypertensive rats. Brain Res 790:151-9
Clemow, D B; McCarty, R; Steers, W D et al. (1997) Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats. Neurourol Urodyn 16:293-303

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